The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition.

@article{Hirose2017ThePP,
  title={The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition.},
  author={Shigenori Hirose and Gong Bei Chen and Adam Kuspa and Gad Shaulsky},
  journal={Journal of cell science},
  year={2017},
  volume={130 23},
  pages={
          4002-4012
        }
}
Allorecognition is a key factor in Dictyostelium development and sociality. It is mediated by two polymorphic transmembrane proteins, TgrB1 and TgrC1, which contain extracellular immunoglobulin domains. TgrB1 and TgrC1 are necessary and sufficient for allorecognition, and they carry out separate albeit overlapping functions in development, but their mechanism of action is unknown. Here, we show that TgrB1 acts as a receptor with TgrC1 as its ligand in cooperative aggregation and differentiation… CONTINUE READING
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