Corpus ID: 30594690

The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.

@article{Fischer1994ThePC,
  title={The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.},
  author={V. Fischer and A. Vickers and F. Heitz and S. Mahadevan and J. Baldeck and P. Minery and R. Tynes},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1994},
  volume={22 2},
  pages={
          269-74
        }
}
  • V. Fischer, A. Vickers, +4 authors R. Tynes
  • Published 1994
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
  • Tropisetron and ondansetron, which are potent and selective 5-hydroxytryptamine (5-HT3) receptor antagonists, were both metabolized by human liver microsomes to several metabolites. These metabolites include the major metabolites found in humans, which are the 5-, 6-, and 7-hydroxy tropisetron and the 7- and 8-hydroxy ondansetron. The cytochrome P-450 (CYP) 2D6 inhibitor quinidine (1 microM) reduced the hydroxylation of tropisetron (67%) and ondansetron (18%). Confirmation of CYP2D6 involvement… CONTINUE READING
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