The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.

@article{Kaetzel2005ThePI,
  title={The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.},
  author={Charlotte Slayton Kaetzel},
  journal={Immunological reviews},
  year={2005},
  volume={206},
  pages={83-99}
}
Secretory antibodies of the immunoglobulin A (IgA) class form the first line of antigen-specific immune protection against inhaled, ingested, and sexually transmitted pathogens and antigens at mucosal surfaces. Epithelial transcytosis of polymeric IgA (pIgA) is mediated by the polymeric immunoglobulin receptor (pIgR). At the apical surface, the extracellular ligand-binding region of pIgR, known as secretory component (SC), is cleaved and released in free form or as a component of secretory IgA… CONTINUE READING
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