Corpus ID: 29206438

The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.

  title={The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.},
  author={C. Gagnon and D. White and J. Cosson and P. Huitorel and B. Edd{\'e} and E. Desbruy{\'e}res and L. Paturle-Lafanech{\`e}re and L. Multigner and D. Job and C. Cibert},
  journal={Journal of cell science},
  volume={109 ( Pt 6)},
  • C. Gagnon, D. White, +7 authors C. Cibert
  • Published 1996
  • Biology, Medicine
  • Journal of cell science
  • To investigate whether a specific isotype of tubulin is involved in flagellar motility, we have developed and screened a panel of monoclonal antibodies (mAb) generated against sea urchin sperm axonemal proteins. Antibodies were selected for their ability to block the motility of permeabilized sperm models. The antitubulin mAb B3 completely inhibited, at low concentrations, the flagellar motility of permeabilized sperm models from four sea urchin species. On immunoblots, B3 recognized… CONTINUE READING
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