The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.

@article{Gagnon1996ThePL,
  title={The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.},
  author={Claude Gagnon and Daniel White and Jacky Cosson and Philippe Huitorel and Bernard Edd{\'e} and Elisabeth Desbruy{\'e}res and L Paturle-Lafanech{\`e}re and Luc Multigner and Didier Job and Christian Cibert},
  journal={Journal of cell science},
  year={1996},
  volume={109 ( Pt 6)},
  pages={1545-53}
}
To investigate whether a specific isotype of tubulin is involved in flagellar motility, we have developed and screened a panel of monoclonal antibodies (mAb) generated against sea urchin sperm axonemal proteins. Antibodies were selected for their ability to block the motility of permeabilized sperm models. The antitubulin mAb B3 completely inhibited, at low concentrations, the flagellar motility of permeabilized sperm models from four sea urchin species. On immunoblots, B3 recognized… CONTINUE READING
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  • M. Belles Isles, C. Chapeau, D. White, C. Gagnon
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