The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information

@inproceedings{Dima2016ThePR,
  title={The polygenic risk for bipolar disorder influences brain regional function relating to visual and default state processing of emotional information},
  author={Danai Dima and Simone de Jong and Gerome Breen and Sophia Frangou},
  booktitle={NeuroImage: Clinical},
  year={2016}
}
Genome-wise association studies have identified a number of common single-nucleotide polymorphisms (SNPs), each of small effect, associated with risk to bipolar disorder (BD). Several risk-conferring SNPs have been individually shown to influence regional brain activation thus linking genetic risk for BD to altered brain function. The current study examined whether the polygenic risk score method, which models the cumulative load of all known risk-conferring SNPs, may be useful in the… CONTINUE READING