The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue

@inproceedings{Kosacka2013ThePI,
  title={The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue},
  author={Joanna Kosacka and Karoline Koch and Martin Gericke and Marcin S Nowicki and John T Heiker and Ingrid Kloeting and Michael Stumvoll and Matthias Bl{\"u}her and Nora Kl{\"o}ting},
  booktitle={Diabetology & metabolic syndrome},
  year={2013}
}
BACKGROUND Recent studies revealed that autophagy is up-regulated in obese individuals, as evidenced by increased expression of autophagy related genes. As argued elsewhere, it is possible that initially insulin resistance functions as an adaptive mechanism to increase autophagy in order to protect cells against death. We have shown that Wistar Ottawa Karlsburg W (RT1(u)) rats (WOKW) develop a metabolic syndrome with insulin resistance in adipose tissue, closely resembling the human disease… CONTINUE READING