The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

@article{Qin2012ThePG,
  title={The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.},
  author={Jinzhong Qin and Warren A. Whyte and Endre Anderssen and Effie Apostolou and Hsu-hsin Chen and Schahram Akbarian and Roderick Terry Bronson and Konrad Hochedlinger and Sridhar Ramaswamy and Richard A Young and Hanno Hock},
  journal={Cell stem cell},
  year={2012},
  volume={11 3},
  pages={
          319-32
        }
}
L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbtl2 results in embryonic lethality with failure of gastrulation. This correlates with compromised proliferation and abnormal differentiation of L3mbtl2(-/-) embryonic stem (ES) cells. L3mbtl2 regulates genes by recruiting a Polycomb Repressive Complex1 (PRC1)-related complex, resembling the previously described E2F6-complex, and… CONTINUE READING

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