The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase

@article{Nag2007ThePT,
  title={The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase},
  author={A. Nag and K. Narsinh and H. Martinson},
  journal={Nature Structural \&Molecular Biology},
  year={2007},
  volume={14},
  pages={662-669}
}
Eukaryotic poly(A) signals direct mRNA 3′-end processing and also pausing and termination of transcription. [...] Key Result Pausing does not require the RNA polymerase II C-terminal domain (CTD) or the cleavage stimulation factor, CstF, that binds the CTD. Pull-down experiments show that CPSF binds, principally through its 30-kDa subunit, to the body of the polymerase. CPSF can also bind CstF, but this seems to be mutually exclusive with polymerase binding. We suggest that CPSF, while binding the body of the…Expand
Polyadenylation releases mRNA from RNA polymerase II in a process that is licensed by splicing.
RNA-binding proteins in regulation of alternative cleavage and polyadenylation.
Mechanisms of mRNA polyadenylation
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