The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death.

@article{Ying2000ThePG,
  title={The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death.},
  author={Weihai Ying and Raymond A Swanson},
  journal={Neuroreport},
  year={2000},
  volume={11 7},
  pages={
          1385-8
        }
}
Poly(ADP-ribose) polymerase (PARP) is now recognized as an important mediator of cell death, but a role for poly(ADP-ribose) glycohydrolase (PARG) in cell death has not previously been described. PARG is the key enzyme degrading ADP-ribose polymers produced by PARP. Here we report effects of the PARG inhibitor gallotannin on oxidative cell death. Pre-incubation of cultured murine astrocytes with as little as 100 nM gallotannin produced significant reductions in H2O2-induced cell death assessed… CONTINUE READING

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