The poly(A)-limiting element is a conserved cis-acting sequence that regulates poly(A) tail length on nuclear pre-mRNAs.

@article{Gu1999ThePE,
  title={The poly(A)-limiting element is a conserved cis-acting sequence that regulates poly(A) tail length on nuclear pre-mRNAs.},
  author={Howard Haogang Gu and Jaydip Das Gupta and Daniel R Schoenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 16},
  pages={8943-8}
}
Most vertebrate mRNAs exit the nucleus with a 200+-residue poly(A) tail and are deadenylated to yield heterogeneous polymers of 50-200 adenosine residues on any given mRNA. We previously reported that Xenopus albumin mRNA and pre-mRNA have an unusually short, discrete 17-residue poly(A) tail and showed that regulation of poly(A) length is controlled independently by two cis-acting poly(A)-limiting elements (PLE A and PLE B) located in the terminal exon. The present study sought to determine the… CONTINUE READING

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Gu et al

  • Sachs, 7 A.B.Mol.Cell.Biol., 3268–3276. 8948 Biochemistry
  • Proc. Natl. Acad. Sci. USA 96
  • 1999
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