The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.

@article{Chase2000ThePK,
  title={The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.},
  author={Diana Chase and C Serafinas and Neville Ashcroft and Mary Kosinski and Dan L. Longo and Douglas K. Ferris and Andy Golden},
  journal={Genesis},
  year={2000},
  volume={26 1},
  pages={26-41}
}
The Polo-like kinases are key regulatory molecules required during the cell cycle for the successful completion of mitosis. We have cloned a C. elegans homolog of the Drosophila melanogaster polo gene (designated plk-1 for C. elegans polo-like kinase-1) and present the subcellular localization of the PLK-1 protein during the meiotic and mitotic cell cycles in C. elegans oocytes and embryos, respectively. Disruption of PLK-1 expression by RNA-mediated interference (RNAi) disrupts normal oocyte… CONTINUE READING

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