The polio-eradication programme and issues of the end game.

@article{Minor2012ThePP,
  title={The polio-eradication programme and issues of the end game.},
  author={Philip D. Minor},
  journal={The Journal of general virology},
  year={2012},
  volume={93 Pt 3},
  pages={
          457-74
        }
}
Poliovirus causes paralytic poliomyelitis, an ancient disease of humans that became a major public-health issue in the 20th century. The primary site of infection is the gut, where virus replication is entirely harmless; the two very effective vaccines developed in the 1950s (oral polio vaccine, or OPV, and inactivated polio vaccine, or IPV) induce humoral immunity, which prevents viraemic spread and disease. The success of vaccination in middle-income and developing countries encouraged the… CONTINUE READING

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Immune Serum From Sabin Inactivated Poliovirus Vaccine Immunization Neutralizes Multiple Individual Wild and Vaccine-Derived Polioviruses.

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