The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.

@article{Nolan2008ThePP,
  title={The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.},
  author={Marissa E. Nolan and Victoria Aranda and Sangjun Lee and Balasubramanian Lakshmi and Srinjan Basu and Donald Craig Allred and Senthil K Muthuswamy},
  journal={Cancer research},
  year={2008},
  volume={68 20},
  pages={8201-9}
}
The polarity protein complex Par6/atypical protein kinase (aPKC)/Cdc42 regulates polarization processes during epithelial morphogenesis, astrocyte migration, and axon specification. We, as well as others, have shown that this complex is also required for disruption of apical-basal polarity during the oncogene ErbB2-induced transformation and transforming growth factor beta-induced epithelial-mesenchymal transition of mammary epithelial cells. Here, we report that expression of Par6 by itself in… CONTINUE READING

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A geneexpression signature as a predictor of survival in breast cancer

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