The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury

@inproceedings{Liu2015ThePM,
  title={The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury},
  author={Haizhou Liu and Wenjin Jason Li and Mark Edmund Rose and Robert W. Hickey and Jun Chen and Guy T Uechi and M. Balasubramani and Billy W. Day and Keyur V. Patel and Steven H Graham},
  booktitle={Cell Death and Disease},
  year={2015}
}
Cyclopentenone prostaglandins (CyPGs), such as 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2), are reactive prostaglandin metabolites exerting a variety of biological effects. CyPGs are produced in ischemic brain and disrupt the ubiquitin-proteasome system (UPS). Ubiquitin-C-terminal hydrolase L1 (UCH-L1) is a brain-specific deubiquitinating enzyme that has been linked to neurodegenerative diseases. Using tandem mass spectrometry (MS) analyses, we found that the C152 site of UCH-L1 is adducted by… CONTINUE READING
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