The podocyte as a direct target of immunosuppressive agents.

  title={The podocyte as a direct target of immunosuppressive agents.},
  author={Eva Schoenenberger and Jochen H. H. Ehrich and Hermann Haller and Mario Schiffer},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={26 1},
Podocytes play a key role in maintaining the blood-urine barrier for high-molecular-weight proteins. They are considered to be terminally differentiated, and podocyte loss cannot be compensated by regenerative proliferation. Various diseases leading to podocyte damage and loss result in proteinuria and cause nephrotic syndrome. Therefore, direct therapeutical strategies to protect podocytes in disease situations are a logical concept to prevent disease or to delay disease progression. Acquired… CONTINUE READING