The pleiotropic actions of leukemia inhibitory factor.

  title={The pleiotropic actions of leukemia inhibitory factor.},
  author={N. M. Gough and Robert L. Williams},
  journal={Cancer cells},
  volume={1 3},
Leukemia inhibitory factor (LIF) is a glycoprotein regulator that induces the differentiation and suppresses the clonogenicity of M1 myeloid leukemic cells. M1 cells require only a brief exposure to LIF to become irreversibly committed to differentiation. In combination with granulocyte colony-stimulating factor or granulocyte-macrophage colony-stimulating factor, LIF is also able to suppress HL-60 and U937 cell proliferation. Normal monocytes and macrophages have LIF receptors, but the… CONTINUE READING