The platelet thrombin receptor and postoperative bleeding.

@article{Ferraris1998ThePT,
  title={The platelet thrombin receptor and postoperative bleeding.},
  author={Victor A. Ferraris and Suellen P. Ferraris and Anurag Singh and W. Fuhr and David Andrew Koppel and Dennis J. McKenna and Espinoza Rodr{\'i}guez and Heather Naomi Reich},
  journal={The Annals of thoracic surgery},
  year={1998},
  volume={65 2},
  pages={
          352-8
        }
}
BACKGROUND We hypothesized that small amounts of thrombin desensitize the platelet thrombin receptor during cardiopulmonary bypass (CPB), resulting in postoperative platelet dysfunction and bleeding. METHODS Seventy-nine patients were entered into a study designed to measure changes in platelet thrombin receptor function during CPB and to correlate them to postoperative bleeding. In addition to measurements of clinical blood loss, platelet function tests of aggregation, activation, and cell… CONTINUE READING

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