The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes.

@article{Spangenberg1993ThePG,
  title={The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes.},
  author={Peter Spangenberg and Herr Emil Redlich and Ilka Bergmann and Wolfgang Loesche and M G{\"o}tzrath and Beate E. Kehrel},
  journal={Thrombosis and haemostasis},
  year={1993},
  volume={70 3},
  pages={514-21}
}
The adhesion of activated platelets to leukocytes (rosette formation) seems to be mediated by CD62 on platelets and its counter-receptor (CD15 or a sialic acid-containing glycoprotein) on polymorphonuclear leukocytes (PMNL). However, neither treatment of platelets with an anti-CD62 antibody or fucoidan nor treatment of PMNL with anti-CD15 antibody or neuraminidase are able to inhibit completely the adhesion. Therefore, we have studied the platelet GPIIb/IIIa complex (CD41a) for its involvement… CONTINUE READING

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