The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells.

@article{Cominacini2003ThePI,
  title={The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells.},
  author={L. Cominacini and A. F. Fratta Pasini and U. Garbin and A. Pastorino and A. Rigoni and C. Nava and A. Davoli and V. Lo Cascio and T. Sawamura},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={41 3},
  pages={
          499-507
        }
}
OBJECTIVES To address the potential role of the endothelial lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the thrombotic system, in this study we first examined whether platelet interaction with LOX-1 generated reactive oxygen species (ROS) and superoxide (O2.-) and then investigated the relationship between the intracellular production of O2.- and the availability of nitric oxide (NO). BACKGROUND Oxidative inactivation of NO is regarded as an important cause of its… Expand
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LOX-1 and ROS, inseparable factors in the process of endothelial damage
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