The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects.

@article{Cattaneo2011ThePP,
  title={The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects.},
  author={Marco Cattaneo},
  journal={Blood},
  year={2011},
  volume={117 7},
  pages={
          2102-12
        }
}
P2Y₁₂, the G(i)-coupled platelet receptor for adenosine diphosphate (ADP), plays a central role in platelet function. Patients with congenital P2Y₁₂ defects display a mild to moderate bleeding diathesis, characterized by mucocutaneous bleedings and excessive post-surgical and post-traumatic blood loss. Defects of P2Y₁₂ should be suspected when ADP, even at high concentrations (≥ 10 μM), is unable to induce full, irreversible platelet aggregation. Tests that evaluate the degree of inhibition of… CONTINUE READING

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