The platelet P2 receptors in thrombosis.

@article{Gachet2005ThePP,
  title={The platelet P2 receptors in thrombosis.},
  author={Christian Gachet and B{\'e}atrice Hechler},
  journal={Seminars in thrombosis and hemostasis},
  year={2005},
  volume={31 2},
  pages={
          162-7
        }
}
Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) play a crucial role in hemostasis and thrombosis, and their receptors are potential targets for antithrombotic drugs. The ATP-gated channel P2X (1) and the two G protein-coupled P2Y (1) and P2Y (12) ADP receptors selectively contribute to platelet aggregation. Because of its central role in the formation and stabilization of a thrombus, the P2Y (12) receptor is a well-established target of antithrombotic drugs such as clopidogrel… CONTINUE READING
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