The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster.

@article{Tatar2011ThePH,
  title={The plate half-full: status of research on the mechanisms of dietary restriction in Drosophila melanogaster.},
  author={Marc Tatar},
  journal={Experimental gerontology},
  year={2011},
  volume={46 5},
  pages={363-8}
}
It has been almost two decades since dietary restriction was first shown to increase Drosophila lifespan. Since then, understanding this phenomenon advanced as groups worked to identify what quality of restricted diet matters: calories or a specific nutrient. The problem is complex because is it difficult to measure what a fly actually consumes. A powerful solution uses the geometric framework of nutrition where diets in many combinations can be tested for their effects on lifespan and… CONTINUE READING
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