The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.

@article{Gerber2009TheP2,
  title={The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells.},
  author={Esther Gerber and Andr{\'e}a Hemmerlin and Michael Hartmann and Dimitri Heintz and M. A. Hartmann and J{\'e}r{\^o}me Mutterer and Manuel Rodr{\'i}guez-Concepc{\'i}on and Albert Boronat and Alain van Dorsselaer and Michel Rohmer and Dring N. Crowell and Thomas J. Bach},
  journal={The Plant cell},
  year={2009},
  volume={21 1},
  pages={285-300}
}
Protein farnesylation and geranylgeranylation are important posttranslational modifications in eukaryotic cells. We visualized in transformed Nicotiana tabacum Bright Yellow-2 (BY-2) cells the geranylgeranylation and plasma membrane localization of GFP-BD-CVIL, which consists of green fluorescent protein (GFP) fused to the C-terminal polybasic domain (BD) and CVIL isoprenylation motif from the Oryza sativa calmodulin, CaM61. Treatment with fosmidomycin (Fos) or oxoclomazone (OC), inhibitors of… CONTINUE READING

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