The plastid-like organelle of apicomplexan parasites as drug target.

  title={The plastid-like organelle of apicomplexan parasites as drug target.},
  author={Jochen Wiesner and Armin Reichenberg and Swetlana Heinrich and Martin Schlitzer and Hassan Jomaa},
  journal={Current pharmaceutical design},
  volume={14 9},
Apicomplexan parasites infectious to humans include Plasmodium spp., Babesia spp., Toxoplasma gondii, Cryptosporidium spp., Isospora belli and Cyclospora cayetanensis. With exception of Cryptosporidium spp., these parasites possess a non-photosynthetic plastid-like organelle called apicoplast. The apicoplast possesses a small circular genome and harbours prokaryotic-type biochemical pathways. As the most important metabolic functions, the mevalonate independent 1-deoxy-D-xylulose 5-phosphate… CONTINUE READING


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