The plasticity-pathology continuum: defining a role for the LTP phenomenon.

  title={The plasticity-pathology continuum: defining a role for the LTP phenomenon.},
  author={J C McEachern and Christopher A. Shaw},
  journal={Journal of neuroscience research},
  volume={58 1},
Long-term potentiation (LTP) is the most widely studied form of neuroplasticity and is believed by many in the field to be the substrate for learning and memory. For this reason, an understanding of the mechanisms underlying LTP is thought to be of fundamental importance to the neurosciences, but a definitive linkage of LTP to learning or memory has not been achieved. Much of the correlational data used to support this claim is ambiguous and controversial, precluding any solid conclusion about… CONTINUE READING
26 Citations
110 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 26 extracted citations


Publications referenced by this paper.
Showing 1-10 of 110 references

The origin of synaptic neuroplasticity: crucial molecules or a dynamical cascade

  • CA Shaw, RA Lanius, K. van den Doel
  • Brain Res Rev 19:241–263
  • 1994
Highly Influential
7 Excerpts

Analysis of the decremental nature of LTP in the dentate gyrus

  • WC Abraham, SE Masonparker, J Williams, M. Dragunow
  • Mol Brain Res 30:367–372.
  • 1995
Highly Influential
4 Excerpts

Traversing levels of organization: neural stability and plasticity

  • CA Shaw, McEachern JC.
  • In: Shaw CA and McEachern JC, editors. Toward a…
  • 2000

Similar Papers

Loading similar papers…