The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.

@article{Hattori2004ThePA,
  title={The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.},
  author={Noboru Hattori and Shinya Mizuno and Yuka Yoshida and Kazuo Chin and Michiaki Mishima and Thomas H. Sisson and Richard H. Simon and Toshikazu Nakamura and Masayuki Miyake},
  journal={The American journal of pathology},
  year={2004},
  volume={164 3},
  pages={1091-8}
}
Mice deficient in the plasminogen activator inhibitor-1 gene (PAI-1-/- mice) are relatively protected from developing pulmonary fibrosis from bleomycin administration. We hypothesized that one of the protective mechanisms may be the ability of the plasminogen system to enhance hepatocyte growth factor (HGF) effects, which have been reported to be anti-fibrotic in the lung. HGF is known to be sequestered in tissues by binding to extracellular matrix components. Following bleomycin administration… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Urokinase and its receptors in chronic kidney disease.

Frontiers in bioscience : a journal and virtual library • 2008
View 12 Excerpts
Highly Influenced

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

American journal of physiology. Lung cellular and molecular physiology • 2015
View 1 Excerpt

Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis.

American journal of physiology. Lung cellular and molecular physiology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…