The plasmacytoma J558L lacks constitutively active NF-kappa B and is deficient in early response gene activation.

@article{Anderson1991ThePJ,
  title={The plasmacytoma J558L lacks constitutively active NF-kappa B and is deficient in early response gene activation.},
  author={Michael G. Anderson and Letitia A. Wims and Sherie L. Morrison},
  journal={Nucleic acids research},
  year={1991},
  volume={19 25},
  pages={7235-41}
}
In mature B cells the nuclear factor NF-kappa B which binds within the kappa enhancer is constitutively present in the nucleus. However, the lambda light chain producing myeloma J558L has been found to lack constitutively functional NF-kappa B. Deoxycholate released functional NF-kappa B from cytoplasmic extracts and functional NF-kappa B was present in J558L following cycloheximide but not phorbol ester treatment. J558L was also unable to respond to phorbol ester stimulation with synthesis of… CONTINUE READING

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