The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides.

@article{Harrington2010ThePM,
  title={The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides.},
  author={John M. Harrington and Justin Widener and Natalie Stephens and Thomas Johnson and Mar{\'i}a Victoria Francia and Paul Capewell and Annette MacLeod and Stephen L. Hajduk},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 37},
  pages={28659-66}
}
Trypanosoma brucei is the causative agent of both a veterinary wasting disease and human African trypanosomiasis, or sleeping sickness. The cell membrane of the developmental stage found within the mammalian host, the bloodstream form (BSF), is highly dynamic, exhibiting rapid rates of endocytosis and lateral flow of glycosylphosphatidylinositol-anchored proteins. Here, we show that the cell membrane of these organisms is a target for killing by small hydrophobic peptides that increase the… CONTINUE READING