The plasma membrane calcium pump in health and disease.

  title={The plasma membrane calcium pump in health and disease.},
  author={Marisa Brini and Tito Cal{\`i} and Denis Ottolini and Ernesto Carafoli},
  journal={The FEBS journal},
  volume={280 21},
The Ca(2+) ATPases of the plasma membrane (PMCA pumps) export Ca(2+) from all eukaryotic cells. In mammals they are the products of four separate genes. PMCA types 1 and 4 are distributed ubiquitously; PMCA types 2 and 3 are restricted to some tissues, the most important being the nervous system. Alternative splicing at two sites greatly increases the number of pump isoforms. The two ubiquitous isoforms are no longer considered as only housekeeping pumps as they also perform tissue-specific… CONTINUE READING
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