The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.

@article{Falchetto1991ThePM,
  title={The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain.},
  author={Rocco Falchetto and T E Vorherr and Josef Brunner and Ernesto Carafoli},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 5},
  pages={2930-6}
}
A synthetic, 28-residue peptide derived from the calmodulin-binding sequence of the plasma membrane Ca2+ pump (C28W) inhibits the ATPase activity of a calpain-produced, truncated fragment of the enzyme. The fragment, which has lost the calmodulin-binding domain, has a molecular mass of 124 kDa and is fully active in the absence of calmodulin. Replacement of Trp-8 in the peptide by an Ala decreases the overall inhibitory activity, while replacement with a Tyr increases it. However, at very low… CONTINUE READING

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Biochemistry 25 , 8372 - 8381 5610 - 5616

  • D. Roufoealis.B.
  • J . Biol . Chem .

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