The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.

@article{Breckenridge1972ThePH,
  title={The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.},
  author={Alasdair Breckenridge and Margaret Orme},
  journal={Life sciences. Pt. 2: Biochemistry, general and molecular biology},
  year={1972},
  volume={11 7},
  pages={
          337-45
        }
}
Abstract The anticoagulant potency of (-)- warfarin is 6.6 times greater than that of (+)- warfarin in male rats. This difference is partly explained by a difference in the plasma half life of the two enantiomers, 15.4 ± 2.8 hours for (-)- warfarin and 8.6 ± 1.6 hours for (+)- warfarin and partly by a difference in the inhibition of prothrombin complex synthesis; (-)- warfarin being 1.9 times more potent than (+)- warfarin. 

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Pharmacokinetics of the warfarin enantiomers in rats

  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1974
VIEW 6 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

Protein binding of warfarin enantiomers in serum of humans and rats

  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1977
VIEW 2 EXCERPTS
CITES BACKGROUND