The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.

@article{Schrch2010ThePC,
  title={The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.},
  author={Regula Sch{\"u}rch and Liliane Todesco and Kateřina Nov{\'a}kov{\'a} and Meike Mevissen and Bruno Stieger and Stephan Kr{\"a}henb{\"u}hl},
  journal={European journal of pharmacology},
  year={2010},
  volume={635 1-3},
  pages={
          171-6
        }
}
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Introduction to the Cellular Transport of Organic Cations

The data show that OCTs play an important physiological role for neurotransmitter balance in the body and, considering their high expression in excretory organs, together with MATEs are responsible for drug excretion.

Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

Whether decreasing the L‐carnitine content represents an effective strategy to decrease accumulation of long‐chain acylc Carnitines and to reduce fatty acid oxidation in order to protect the heart against acute ischaemia–reperfusion injury is tested.

References

SHOWING 1-10 OF 35 REFERENCES

Renal adaptation to dietary carnitine in humans.

It is concluded that the kidney adapts to carnitine intake by reducing the efficiency of carnitines reabsorption by using the glomerular filtration rate.

Relationship between acid-soluble carnitine and coenzyme A pools in vivo.

Results support the concept that the carnitine/acid-soluble acylcarnitine pool reflects changes in, rather than inducingChanges in, the hepatic CoA/acyl-CoA pool.

PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation.

Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

OCTN2 is a physiologically important, high affinity sodium-carnitine cotransporter in humans, and the functional characteristics of OCTN2 coincide with those reported for plasma membrane carnitine transport.

Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats.

Insulin stimulates L‐carnitine accumulation in human skeletal muscle

It is demonstrated that insulin can acutely increase muscle TC content in humans during hypercarnitinemia, which is associated with an increase in OCTN2 transcription, which may be of importance to the regulation of muscle fat oxidation during exercise, particularly in obesity and type 2 diabetes where it is known to be impaired.

Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans.

Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species.

Development and characterization of an animal model of carnitine deficiency.

THP inhibits butyrobetaine hydroxylase competitively, blocks carnitine biosynthesis in vivo and interacts competitively with renal carnitin reabsorption, and can therefore serve as an animal model for human carnitines deficiency.

Characterization of L-carnitine transport by rat kidney brush-border-membrane vesicles.

In the presence of a 100 mM Na+ gradient, transport of L-carnitine into rat renal brush-border-membrane vesicles was linear over 30 s and showed an overshoot at 5 min, suggesting an electrogenic mechanism.