The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.
@article{Schrch2010ThePC, title={The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.}, author={Regula Sch{\"u}rch and Liliane Todesco and Kateřina Nov{\'a}kov{\'a} and Meike Mevissen and Bruno Stieger and Stephan Kr{\"a}henb{\"u}hl}, journal={European journal of pharmacology}, year={2010}, volume={635 1-3}, pages={ 171-6 } }
14 Citations
Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians
- MedicineEuropean Journal of Nutrition
- 2015
Oral l-carnitine supplementation normalizes the plasma carnitine stores and slightly increases the skeletal muscle carnitines content in vegetarians, but without affecting muscle function and energy metabolism.
Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
- BiologyThe Journal of physiology
- 2017
Novel findings support the premise that muscle carnitine availability is a primary regulator of fuel selection in vivo and the modulation of discrete cellular functions and metabolic pathways.
Clozapine‐induced reduction of l‐carnitine reabsorption via inhibition/down‐regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice
- Medicine, BiologyToxicology and applied pharmacology
- 2019
PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
- BiologyInternational journal of molecular sciences
- 2022
A second stimulatory pathway of SLC22A5 gene transcription in skeletal muscle is detected, which involves the nuclear transcription factor MEF2 and co-stimulation by PGC-1α and which is controlled by the p38 MAPK signaling cascade.
Effect of Acetyl-l-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats
- Biology, MedicineNeurochemical Research
- 2019
Treatment of pups with ALCAR after HI prevented the decrease in renal OCTN2 and PDH levels at 24 h after injury, which would improve energy metabolism in kidney, maintain tissue carnitine levels and overall Carnitine homeostasis which is essential for neonatal health.
Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational perio.
- BiologyReproductive toxicology
- 2020
Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.
- Biology, MedicineMolecular nutrition & food research
- 2011
Findings indicate that regular EE reverses an HF diet-induced impairment of hepatic carnitine content by stimulating hepatic Carnitine synthesis and uptake.
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
- Biology, MedicinePharmacological research
- 2016
Introduction to the Cellular Transport of Organic Cations
- Biology
- 2016
The data show that OCTs play an important physiological role for neurotransmitter balance in the body and, considering their high expression in excretory organs, together with MATEs are responsible for drug excretion.
Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction
- BiologyBritish journal of pharmacology
- 2015
Whether decreasing the L‐carnitine content represents an effective strategy to decrease accumulation of long‐chain acylc Carnitines and to reduce fatty acid oxidation in order to protect the heart against acute ischaemia–reperfusion injury is tested.
References
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