The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.

@article{Schrch2010ThePC,
  title={The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.},
  author={Regula Sch{\"u}rch and Liliane Todesco and Kateřina Nov{\'a}kov{\'a} and Meike Mevissen and Bruno Stieger and Stephan Kr{\"a}henb{\"u}hl},
  journal={European journal of pharmacology},
  year={2010},
  volume={635 1-3},
  pages={
          171-6
        }
}
View on PubMed
zora.uzh.ch
14 Citations
Background Citations
7
Results Citations
1

Tables from this paper

14 Citations

Effect of Short- and Long-Term Treatment With Valproate on Carnitine Homeostasis in Humans

The initial drop in plasma carnitine levels of valproate-treated patients is most likely due to impaired carn itine biosynthesis, whereas the recovery of the plasma carnItine levels is explainable by an increased renal expression of OCTN2.

Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians

Oral l-carnitine supplementation normalizes the plasma carnitine stores and slightly increases the skeletal muscle carnitines content in vegetarians, but without affecting muscle function and energy metabolism.

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent

Novel findings support the premise that muscle carnitine availability is a primary regulator of fuel selection in vivo and the modulation of discrete cellular functions and metabolic pathways.

Clozapine‐induced reduction of l‐carnitine reabsorption via inhibition/down‐regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice

PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle

A second stimulatory pathway of SLC22A5 gene transcription in skeletal muscle is detected, which involves the nuclear transcription factor MEF2 and co-stimulation by PGC-1α and which is controlled by the p38 MAPK signaling cascade.

Effect of Acetyl-l-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats

Treatment of pups with ALCAR after HI prevented the decrease in renal OCTN2 and PDH levels at 24 h after injury, which would improve energy metabolism in kidney, maintain tissue carnitine levels and overall Carnitine homeostasis which is essential for neonatal health.

Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: An analysis by gestational perio.

Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.

Findings indicate that regular EE reverses an HF diet-induced impairment of hepatic carnitine content by stimulating hepatic Carnitine synthesis and uptake.

Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.

Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

Whether decreasing the L‐carnitine content represents an effective strategy to decrease accumulation of long‐chain acylc Carnitines and to reduce fatty acid oxidation in order to protect the heart against acute ischaemia–reperfusion injury is tested.

References

SHOWING 1-10 OF 35 REFERENCES

Renal adaptation to dietary carnitine in humans.

It is concluded that the kidney adapts to carnitine intake by reducing the efficiency of carnitines reabsorption by using the glomerular filtration rate.

Relationship between acid-soluble carnitine and coenzyme A pools in vivo.

Results support the concept that the carnitine/acid-soluble acylcarnitine pool reflects changes in, rather than inducingChanges in, the hepatic CoA/acyl-CoA pool.

PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation.

Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

OCTN2 is a physiologically important, high affinity sodium-carnitine cotransporter in humans, and the functional characteristics of OCTN2 coincide with those reported for plasma membrane carnitine transport.

Mechanisms of liver steatosis in rats with systemic carnitine deficiency due to treatment with trimethylhydraziniumpropionate.

Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats.

Insulin stimulates L‐carnitine accumulation in human skeletal muscle

It is demonstrated that insulin can acutely increase muscle TC content in humans during hypercarnitinemia, which is associated with an increase in OCTN2 transcription, which may be of importance to the regulation of muscle fat oxidation during exercise, particularly in obesity and type 2 diabetes where it is known to be impaired.

Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans.

Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species.

Development and characterization of an animal model of carnitine deficiency.

THP inhibits butyrobetaine hydroxylase competitively, blocks carnitine biosynthesis in vivo and interacts competitively with renal carnitin reabsorption, and can therefore serve as an animal model for human carnitines deficiency.