The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

@inproceedings{Oliveira2018ThePB,
  title={The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus},
  author={Jo{\~a}o J. Oliveira and Sarah Karrar and Daniel B Rainbow and Christopher L Pinder and Pamela N. Clarke and Arcadio Rubio Garc{\'i}a and Osama Al-Assar and Keith Burling and Timothy J. Vyse and Linda S. Wicker and John A. Todd and Ricardo C. Ferreira},
  year={2018}
}
The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here we have evaluated the diagnostic and clinical value of a robust, inexpensive, immunoassay detecting the circulating soluble form of the monocyte-specific surface receptor sialic acid binding Ig-like lectin 1 (sSIGLEC-1). We developed an immunoassay to measure sSIGLEC-1 in small volumes of plasma/serum from systemic lupus… CONTINUE READING