The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients.

@article{Crommentuyn2004ThePA,
  title={The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients.},
  author={Kristel M L Crommentuyn and Jan Willem Mulder and Albert T. A. Mairuhu and Eric van Gorp and Pieter L. Meenhorst and Alwin D. R. Huitema and Jos H. Beijnen},
  journal={Antiviral therapy},
  year={2004},
  volume={9 5},
  pages={779-85}
}
Therapeutic drug monitoring of protease inhibitors (PIs) is usually performed on plasma samples although their antiretroviral effect takes place inside cells. Little is known, however, about the intracellular accumulation and related plasma pharmacokinetics of PIs such as lopinavir/ritonavir (LPV/RTV). Therefore, we studied the plasma and intracellular (cell-associated) steady-state pharmacokinetics of this PI combination in a dosage of 400/100 mg twice daily in a non-randomized cohort of HIV-1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…