The plant ribosome inactivating protein saporin induces micronucleus formation in peripheral human lymphocytes in vitro.

@article{Poma1999ThePR,
  title={The plant ribosome inactivating protein saporin induces micronucleus formation in peripheral human lymphocytes in vitro.},
  author={Anna Poma and Osvaldo Zarivi and Silvia Bianchini and Lukas Spano},
  journal={Toxicology letters},
  year={1999},
  volume={105 1},
  pages={
          67-73
        }
}
Saporin belongs to the family of plant enzymes known as ribosome inactivating proteins (RIPs) for their property to depurinate the major rRNA, thus leading to inactivation of ribosomes. In this work we analyzed the genotoxic effects of saporin, purified from root cultures of Saponaria officinalis, by evaluating micronucleus formation and by the quantitative determination of cytosolic histone-associated DNA fragments. Saporin induces micronuclei formation in cultured human lymphocytes in a dose… CONTINUE READING
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