The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity.

@article{Dul2007ThePH,
  title={The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity.},
  author={Barbara E Dul and Nancy C Walworth},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 25},
  pages={18397-406}
}
The DNA damage checkpoint pathway governs how cells regulate cell cycle progression in response to DNA damage. A screen for suppressors of a fission yeast chk1 mutant defective in the checkpoint pathway identified a novel Schizosaccharomyces pombe protein, Msc1. Msc1 contains 3 plant homeodomain (PHD) finger motifs, characteristically defined by a C4HC3 consensus similar to RING finger domains. PHD finger domains in viral proteins and in the cellular protein kinase MEKK1 (mitogen-activated… CONTINUE READING

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