The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.

@article{RamnMaiques2007ThePH,
  title={The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.},
  author={Santiago Ram{\'o}n-Maiques and Alex J. Kuo and Dylan Carney and Adam Matthews and Marjorie A. Oettinger and Or P Gozani and Wei Yang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 48},
  pages={18993-8}
}
Recombination activating gene (RAG) 1 and RAG2 together catalyze V(D)J gene rearrangement in lymphocytes as the first step in the assembly and maturation of antigen receptors. RAG2 contains a plant homeodomain (PHD) near its C terminus (RAG2-PHD) that recognizes histone H3 methylated at lysine 4 (H3K4me) and influences V(D)J recombination. We report here… CONTINUE READING