The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells.

@article{Mosca1992ThePA,
  title={The plant amino acid mimosine may inhibit initiation at origins of replication in Chinese hamster cells.},
  author={P J Mosca and Pieter A. Dijkwel and Joyce L. Hamlin},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 10},
  pages={4375-83}
}
An understanding of replication initiation in mammalian cells has been hampered by the lack of mutations and/or inhibitors that arrest cells just prior to entry into the S period. The plant amino acid mimosine has recently been suggested to inhibit cells at a regulatory step in late G1. We have examined the effects of mimosine on cell cycle traverse in the mimosine [corrected]-resistant CHO cell line CHOC 400. When administered to cultures for 14 h after reversal of a G0 block, the drug appears… CONTINUE READING

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