The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development

@inproceedings{Gray2009ThePC,
  title={The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis, and mouse embryonic development},
  author={Ryan S. Gray and Philip Barron Abitua and Bogdan J. Wlodarczyk and Heather L. Szabo-Rogers and Otis Blanchard and Insuk Lee and Greg S. Weiss and Karen J Liu and Edward M. Marcotte and John B. Wallingford and Richard H. Finnell},
  booktitle={Nature Cell Biology},
  year={2009}
}
The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP' proteins, such as Dishevelled and Frizzled, have been extensively characterized. By contrast, the 'PCP effector' proteins, such as Intu and Fuz, remain largely unstudied. These proteins are essential for PCP signalling, but they have never been investigated in mammals and their cell biological activities remain entirely unknown. We report here… CONTINUE READING
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