The plakoglobin knock-out mouse: a paradigm for the molecular analysis of cardiac cell junction formation.

@article{Ruiz1998ThePK,
  title={The plakoglobin knock-out mouse: a paradigm for the molecular analysis of cardiac cell junction formation.},
  author={Phillip Ruiz and Walter Birchmeier},
  journal={Trends in cardiovascular medicine},
  year={1998},
  volume={8 3},
  pages={97-101}
}
Plakoglobin (γ-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaques of desmosomes and adherens junctions and is involved in anchorage of cytoskeletal filaments to specific cadherins. When the plakoglobin gene is ablated in mice, animals die between days 12 and 16 of embryogenesis owing to defects in heart… CONTINUE READING