The place for short-acting opioids: special emphasis on remifentanil

  title={The place for short-acting opioids: special emphasis on remifentanil},
  author={Wolfram Wilhelm and Sascha Kreuer},
  journal={Critical Care},
  pages={S5 - S5}
Pain is among the worst possible experiences for the critically ill. Therefore, nearly all intensive care patients receive some kind of pain relief, and opioids are most frequently administered. Morphine has a number of important adverse effects, including histamine release, pruritus, constipation, and, in particular, accumulation of morphine-6-glucuronide in patients with renal impairment. Hence, it is not an ideal analgesic for use in critically ill patients. Although the synthetic opioids… CONTINUE READING
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