The pivotal twin histidines and aromatic triad of the Escherichia coli ammonium channel AmtB can be replaced.

Abstract

In Escherichia coli, each subunit of the trimeric channel protein AmtB carries a hydrophobic pore for transport of NH(4)(+) across the cytoplasmic membrane. Positioned along this substrate conduction pathway are two conserved elements--a pair of hydrogen-bonded histidines (H168/H318) located within the pore itself and a set of aromatic residues (F107/W148… (More)
DOI: 10.1073/pnas.1108451108

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