The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis.

@article{Dayer2003ThePR,
  title={The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis.},
  author={Jean-Michel Dayer},
  journal={Rheumatology},
  year={2003},
  volume={42 Suppl 2},
  pages={ii3-10}
}
The role of the cytokine network in mediating inflammation and joint destruction in rheumatoid arthritis (RA) has been investigated extensively in recent years. Interleukin-1 (IL-1) and tumour necrosis factor alpha (TNFalpha) are two pivotal proinflammatory cytokines that have been shown to contribute to the clinical manifestations of RA. The ability of IL-1 to drive inflammation and joint erosion and to inhibit tissue repair processes has been clearly established in in vitro systems and animal… CONTINUE READING

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