The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin.

@article{Langevin1993ThePR,
  title={The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin.},
  author={Helene M Langevin and Andrew R Fischer and Mitchell A Rosenberg and Craig M. Lilly and J C Callery and Joseph 1. Shapiro and Jeffrey Cohn and Peter J Rubin and Jeffrey M Drazen},
  journal={The American review of respiratory disease},
  year={1993},
  volume={148 6 Pt 1},
  pages={1447-51}
}
A subset of persons with asthma develop bronchospasm, naso-ocular, gastrointestinal, and/or dermal reactions after ingesting aspirin (ASA) or agents with the capacity to inhibit cyclooxygenase. The bronchopulmonary reactions have been associated with a rise in urinary LTE4. We examined the effects of an inhibitor of 5-lipoxygenase, zileuton, in a group of eight asthmatic patients with known sensitivity to ASA accompanied by LTE4 hyperexcretion. We first confirmed ASA sensitivity and an increase… CONTINUE READING