The pivotal regulatory landscape of RNA modifications.

  title={The pivotal regulatory landscape of RNA modifications.},
  author={Sheng Li and Christopher E. Mason},
  journal={Annual review of genomics and human genetics},
Posttranscriptionally modified nucleosides in RNA play integral roles in the cellular control of biological information that is encoded in DNA. The modifications of RNA span all three phylogenetic domains (Archaea, Bacteria, and Eukarya) and are pervasive across RNA types, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and (less frequently) small nuclear RNA (snRNA) and microRNA (miRNA). Nucleotide modifications are also one of the most evolutionarily conserved… CONTINUE READING