The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging

@article{Beekman2006ThePG,
  title={The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging},
  author={F. Beekman and F. V. D. Have},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2006},
  volume={34},
  pages={151-161}
}
  • F. Beekman, F. V. D. Have
  • Published 2006
  • Computer Science, Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
Today the majority of clinical molecular imaging procedures are carried out with single-photon emitters and gamma cameras, in planar mode and single-photon emission computed tomography (SPECT) mode. Thanks to the development of advanced multi-pinhole collimation technologies, SPECT imaging of small experimental animals is rapidly gaining in popularity. Whereas resolutions in routine clinical SPECT are typically larger than 1 cm (corresponding to >1,000 μl), it has recently proved possible to… Expand
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References

SHOWING 1-10 OF 87 REFERENCES
Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals
Pinhole collimation of gamma rays to image distributions of radiolabeled tracers is considered promising for use in small animal imaging. The recent availability of transgenic mice, coupled with theExpand
Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes
TLDR
It is demonstrated how a basic and compact gamma camera can be constructed for in vivo radionuclide imaging in small animals, at much higher spatial resolution, using this simple bench-top camera. Expand
U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice.
TLDR
The initial in vivo images of the mouse heart and spine show that U-SPECT-I can be used for novel applications in the study of dynamic biologic systems with a clear projection to clinical applications and opens up new possibilities for the suborgan-level study of radiotracers in mouse models. Expand
Ultra-high resolution SPECT system using four pinhole collimators for small animal studies.
  • K. Ishizu, T. Mukai, +7 authors J. Konishi
  • Physics, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1995
TLDR
This ultra-high resolution SPECT system can be used to measure the regional distribution of radiolabeled tracers in small animals in vivo and may play a significant role in the development of new radiopharmaceuticals and in studies of various disease models using living animals. Expand
A multipinhole small animal SPECT system with submillimeter spatial resolution.
TLDR
A multipinhole small animal imaging system based on position sensitive avalanche photodiode (PSAPD) detectors with the goal of submillimeter spatial resolution and high detection efficiency, which will allow us to minimize the radiation dose to the animal and to shorten the time needed for the imaging study. Expand
Small-animal radionuclide imaging with focusing gamma-ray optics
Significant effort currently is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other smallExpand
A new reconstruction strategy for image improvement in pinhole SPECT
  • T. Zeniya, H. Watabe, +6 authors H. Iida
  • Computer Science, Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • 2004
TLDR
Axial blurring is hypothesised to be due to incompleteness of the projection data acquired by a single circular pinhole orbit, and a new strategy for accurate image reconstruction with better spatial resolution uniformity is evaluated. Expand
ECG-gated pinhole SPECT in mice with millimeter spatial resolution
The authors have developed a single photon emission computed tomography (SPECT) technique for high resolution radiotracer imaging of mice where the object is rotated instead of the scintillationExpand
Evaluation of high-resolution pinhole SPECT using a small rotating animal.
TLDR
A rotating cylinder mechanism for pinhole SPECT is feasible and shows the same characteristics as conventional pin hole SPECT with a rotating camera head, without distortion artifacts. Expand
Submillimeter total-body murine imaging with U-SPECT-I.
  • B. Vastenhouw, F. Beekman
  • Physics, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2007
TLDR
In addition to providing ultra-high-resolution images of mouse organs, focusing SPECT pinhole systems are also suitable for submillimeter-resolution total-body imaging of mice. Expand
...
1
2
3
4
5
...