The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man

@article{Esposti1988ThePG,
  title={The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man},
  author={D. Esposti and Paolo Lissoni and Rubens Mauri and Franco Rovelli and Luigi Orsenigo and Simonetta Pescia and Giorgio Vegetti and G. Degli Esposti and Franco Fraschini},
  journal={Journal of Endocrinological Investigation},
  year={1988},
  volume={11},
  pages={103-106}
}
Several observations have demonstrated that the opioid system can modulate melatonin secretion from the pineal gland and that the effects of opioids may require a pineal participation. In contrast, the role played by the pineal gland in regulating the synthesis and secretion of endorphins and enkephalins in still obscure. To establish whether the neuroendocrine activity of melatonin are mediated by endogenous opioids and to demonstrate a possible action exerted by the pineal gland on opioid… CONTINUE READING