The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin.

@article{Gonciarz2010ThePS,
  title={The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin.},
  author={Maciej Gonciarz and Zbigniew Gonciarz and Wladyslaw Bielański and Aldona Mularczyk and Piotr C. Konturek and Tomasz Brzozowski and Stanisław Jan Konturek},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2010},
  volume={61 6},
  pages={705-10}
}
The mechanism by which nonalcoholic fatty liver disease (NAFLD) progresses into nonalcoholic steatohepatitis (NASH) is unknown, however, the major process is oxidative stress with increased production of reactive oxygen species and excessive inflammatory cytokine generation. To date, there are no effective treatments for NASH and the published data with treatment using antioxidants are not satisfactory. Melatonin (MT), the potent endogenous antioxidant secreted in circadian rhythm by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…