• DOI:10.1080/01677063.2017.1395876
Corpus ID: 1351539

The pigmented epithelium, a bright partner against photoreceptor degeneration

@article{Letelier2017ThePE,
  title={The pigmented epithelium, a bright partner against photoreceptor degeneration},
  author={J. Letelier and P. Bovolenta and J. R. Mart{\'i}nez-Morales},
  journal={Journal of Neurogenetics},
  year={2017},
  volume={31},
  pages={203 - 215}
}

• J. Letelier, P. Bovolenta, J. R. Martínez-Morales
• Published 2017
• Biology, Medicine
• Journal of Neurogenetics

Abstract Sight depends on the intimate association between photoreceptors and pigment epithelial cells. The evolutionary origin of this cellular tandem can be traced back to the emergence of bilateral animals, at least 450 million years ago, as they define the minimal unit of the ancestral prototypic eye. Phototransduction is a demanding process from the energetic and homeostatic points of view, and not surprisingly photoreceptive cells are particularly susceptible to damage and degeneration… Expand

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