The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.

  title={The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.},
  author={Craig C. Mello and Bruce W Draper and Michael Krause and Harold Weintraub and James R Priess},
  volume={70 1},
During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 121 extracted citations

Comparative aspects of animal oogenesis.

Developmental biology • 2001
View 4 Excerpts
Highly Influenced

Repression of somatic cell fate in the germline

Cellular and Molecular Life Sciences • 2015
View 3 Excerpts
Highly Influenced

Cell fate specification in the C. elegans embryo.

Developmental dynamics : an official publication of the American Association of Anatomists • 2010
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 34 references

Programmed cell death in nematode development

K. J. Kemphues, J. R. Priess, D. G. Morton, N. Cheng
Neurosci . Comment • 1988
View 7 Excerpts
Highly Influenced


S. Brenner
View 3 Excerpts
Highly Influenced

Reversal of cellular polarity and early cell - cell interaction in the embryo of Caenofhabditis elegens

D. St Johnston, C. Nusslein-Volhard
Dev . Biol . • 1992

expression in Caenorhabditis elegans

B. Goldstein
View 1 Excerpt

Similar Papers

Loading similar papers…