The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.

@article{Mello1992ThePA,
  title={The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.},
  author={Craig C. Mello and Bruce W Draper and Michael Krause and Harold Weintraub and James R Priess},
  journal={Cell},
  year={1992},
  volume={70 1},
  pages={163-76}
}
During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres… CONTINUE READING
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